TY - JOUR
T1 - Present and Future of Cardiac Troponin in Clinical Practice
T2 - A Paradigm Shift to High-Sensitivity Assays
AU - Sandoval, Yader
AU - Smith, Stephen W.
AU - Apple, Fred S.
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Despite its wide utilization and central role in the evaluation of patients with potential ischemic symptoms, misconceptions and confusion about cardiac troponin (cTn) prevail. The implementation of high-sensitivity (hs) cTn assays in clinical practice has multiple potential advantages provided there is an education process tied to the introduction of these assays that emphasizes the appropriate utilization of the test. Several diagnostic strategies have been explored with hs-cTn assays, including the use of undetectable values, accelerated serial hs-cTn sampling, hs-cTn measurements in combination with a clinical-risk score, and the use of a single hs-cTn measurement with a concentration threshold tailored to meet a clinical need. In this document we discuss basic concepts that should facilitate the integration of hs-cTn assays into clinical care in years to come.
AB - Despite its wide utilization and central role in the evaluation of patients with potential ischemic symptoms, misconceptions and confusion about cardiac troponin (cTn) prevail. The implementation of high-sensitivity (hs) cTn assays in clinical practice has multiple potential advantages provided there is an education process tied to the introduction of these assays that emphasizes the appropriate utilization of the test. Several diagnostic strategies have been explored with hs-cTn assays, including the use of undetectable values, accelerated serial hs-cTn sampling, hs-cTn measurements in combination with a clinical-risk score, and the use of a single hs-cTn measurement with a concentration threshold tailored to meet a clinical need. In this document we discuss basic concepts that should facilitate the integration of hs-cTn assays into clinical care in years to come.
KW - Acute myocardial infarction
KW - High-sensitivity cardiac troponin
KW - Troponin
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U2 - 10.1016/j.amjmed.2015.12.005
DO - 10.1016/j.amjmed.2015.12.005
M3 - Review article
C2 - 26743351
AN - SCOPUS:84957050550
SN - 0002-9343
VL - 129
SP - 354
EP - 365
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 4
ER -
