Presence of immunocytes and sulfidopeptide leukotrienes in the inflamed guinea pig distal colon

David M. Hammerbeck, David R. Brown

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

This study examined whether the immunocyte recruitment associated with a mild inflammatory state induced by acetic acid would produce detectable sulfido-peptide leukotriene (LT) levels from colonic tissues or in dialysates. Histological examination and measurements of peroxidase activities of inflamed tissues indicated edema, hyperplasia and neutrophil infiltration. Significant elevated LTB4 and prostaglandin E2 (PGE2) levels were found but only slight elevations in sulfidopeptide LTs occurred. A slight elevation in eosinophil peroxidase indicated that eosinophil infiltration also occurred. The increase in sulfidopeptide LT levels appeared insufficient by itself to alter secretory reponses in the distal colon. However, combined with other immunocyte products such as PGs, the sulfidopeptide LTs may influence the symptomology of inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)413-425
Number of pages13
JournalInflammation
Volume20
Issue number4
DOIs
StatePublished - Jan 1 1996

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