Presence of a high-flow-mediated constriction phenomenon prior to flow-mediated dilation in normal weight, overweight, and obese children and adolescents

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: When assessing vasomotor endothelial function by reactive hyperemia, the brachial artery, in some individuals, constricts immediately before beginning to dilate following cuff release. We call this response high-flow-mediated constriction (H-FMC). The aim of this study was to describe the rate of the H-FMC during reactive hyperemia in children and adolescents throughout a range of body mass index (BMI) values, and to investigate differences in flow-mediated dilation (FMD), cardiovascular, and anthropometric measures between subjects with and without H-FMC. Methods: FMD was assessed in 136 children and adolescents (61 male, 75 female; 13±3 years) by sonographic imaging of the brachial artery. H-FMC was characterized as the lowest point from the baseline brachial artery diameter immediately following reactive cuff release. Independent t tests were used to compare subjects with and without H-FMC. Results: H-FMC was observed in 91 of the 136 participants (66.9%). No significant difference was found between H-FMC and non-H-FMC subjects for age (p=0.602), gender (p=0.767), height (p=0.227), or weight (p=0.171). BMI percentile was nonsignificantly higher (91.8±14.9th versus 84.6±22.8th percentile, p=0.057) and FMD was significantly lower (5.43±3.41% versus 8.05±3.97%, p<0.001) in H-FMC than in non-H-FMC subjects. Adding H-FMC to FMD produced no significant difference between H-FMC and non-H-FMC individuals (8.03±3.27% versus 8.05±3.97%, p=0.977). Conclusions: Approximately 67% of participants demonstrated an H-FMC during reactive hyperemia. BMI percentile was nonsignificantly higher and FMD was significantly lower in children and adolescents who displayed this phenomenon.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalJournal of Clinical Ultrasound
Volume43
Issue number8
DOIs
StatePublished - Oct 1 2015

Fingerprint

Constriction
Dilatation
Weights and Measures
Brachial Artery
Hyperemia
Body Mass Index

Keywords

  • Adolescents
  • Flow-mediated constriction
  • Flow-mediated dilation
  • Reactive hyperemia
  • Ultrasound

Cite this

@article{af3b7371aaeb4ddcab8f66f2017bb3ff,
title = "Presence of a high-flow-mediated constriction phenomenon prior to flow-mediated dilation in normal weight, overweight, and obese children and adolescents",
abstract = "Purpose: When assessing vasomotor endothelial function by reactive hyperemia, the brachial artery, in some individuals, constricts immediately before beginning to dilate following cuff release. We call this response high-flow-mediated constriction (H-FMC). The aim of this study was to describe the rate of the H-FMC during reactive hyperemia in children and adolescents throughout a range of body mass index (BMI) values, and to investigate differences in flow-mediated dilation (FMD), cardiovascular, and anthropometric measures between subjects with and without H-FMC. Methods: FMD was assessed in 136 children and adolescents (61 male, 75 female; 13±3 years) by sonographic imaging of the brachial artery. H-FMC was characterized as the lowest point from the baseline brachial artery diameter immediately following reactive cuff release. Independent t tests were used to compare subjects with and without H-FMC. Results: H-FMC was observed in 91 of the 136 participants (66.9{\%}). No significant difference was found between H-FMC and non-H-FMC subjects for age (p=0.602), gender (p=0.767), height (p=0.227), or weight (p=0.171). BMI percentile was nonsignificantly higher (91.8±14.9th versus 84.6±22.8th percentile, p=0.057) and FMD was significantly lower (5.43±3.41{\%} versus 8.05±3.97{\%}, p<0.001) in H-FMC than in non-H-FMC subjects. Adding H-FMC to FMD produced no significant difference between H-FMC and non-H-FMC individuals (8.03±3.27{\%} versus 8.05±3.97{\%}, p=0.977). Conclusions: Approximately 67{\%} of participants demonstrated an H-FMC during reactive hyperemia. BMI percentile was nonsignificantly higher and FMD was significantly lower in children and adolescents who displayed this phenomenon.",
keywords = "Adolescents, Flow-mediated constriction, Flow-mediated dilation, Reactive hyperemia, Ultrasound",
author = "Ostrem, {Joseph D.} and Evanoff, {Nicholas G} and Kelly, {Aaron S} and Dengel, {Donald R}",
year = "2015",
month = "10",
day = "1",
doi = "10.1002/jcu.22267",
language = "English (US)",
volume = "43",
pages = "495--501",
journal = "Journal of Clinical Ultrasound",
issn = "0091-2751",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Presence of a high-flow-mediated constriction phenomenon prior to flow-mediated dilation in normal weight, overweight, and obese children and adolescents

AU - Ostrem, Joseph D.

AU - Evanoff, Nicholas G

AU - Kelly, Aaron S

AU - Dengel, Donald R

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Purpose: When assessing vasomotor endothelial function by reactive hyperemia, the brachial artery, in some individuals, constricts immediately before beginning to dilate following cuff release. We call this response high-flow-mediated constriction (H-FMC). The aim of this study was to describe the rate of the H-FMC during reactive hyperemia in children and adolescents throughout a range of body mass index (BMI) values, and to investigate differences in flow-mediated dilation (FMD), cardiovascular, and anthropometric measures between subjects with and without H-FMC. Methods: FMD was assessed in 136 children and adolescents (61 male, 75 female; 13±3 years) by sonographic imaging of the brachial artery. H-FMC was characterized as the lowest point from the baseline brachial artery diameter immediately following reactive cuff release. Independent t tests were used to compare subjects with and without H-FMC. Results: H-FMC was observed in 91 of the 136 participants (66.9%). No significant difference was found between H-FMC and non-H-FMC subjects for age (p=0.602), gender (p=0.767), height (p=0.227), or weight (p=0.171). BMI percentile was nonsignificantly higher (91.8±14.9th versus 84.6±22.8th percentile, p=0.057) and FMD was significantly lower (5.43±3.41% versus 8.05±3.97%, p<0.001) in H-FMC than in non-H-FMC subjects. Adding H-FMC to FMD produced no significant difference between H-FMC and non-H-FMC individuals (8.03±3.27% versus 8.05±3.97%, p=0.977). Conclusions: Approximately 67% of participants demonstrated an H-FMC during reactive hyperemia. BMI percentile was nonsignificantly higher and FMD was significantly lower in children and adolescents who displayed this phenomenon.

AB - Purpose: When assessing vasomotor endothelial function by reactive hyperemia, the brachial artery, in some individuals, constricts immediately before beginning to dilate following cuff release. We call this response high-flow-mediated constriction (H-FMC). The aim of this study was to describe the rate of the H-FMC during reactive hyperemia in children and adolescents throughout a range of body mass index (BMI) values, and to investigate differences in flow-mediated dilation (FMD), cardiovascular, and anthropometric measures between subjects with and without H-FMC. Methods: FMD was assessed in 136 children and adolescents (61 male, 75 female; 13±3 years) by sonographic imaging of the brachial artery. H-FMC was characterized as the lowest point from the baseline brachial artery diameter immediately following reactive cuff release. Independent t tests were used to compare subjects with and without H-FMC. Results: H-FMC was observed in 91 of the 136 participants (66.9%). No significant difference was found between H-FMC and non-H-FMC subjects for age (p=0.602), gender (p=0.767), height (p=0.227), or weight (p=0.171). BMI percentile was nonsignificantly higher (91.8±14.9th versus 84.6±22.8th percentile, p=0.057) and FMD was significantly lower (5.43±3.41% versus 8.05±3.97%, p<0.001) in H-FMC than in non-H-FMC subjects. Adding H-FMC to FMD produced no significant difference between H-FMC and non-H-FMC individuals (8.03±3.27% versus 8.05±3.97%, p=0.977). Conclusions: Approximately 67% of participants demonstrated an H-FMC during reactive hyperemia. BMI percentile was nonsignificantly higher and FMD was significantly lower in children and adolescents who displayed this phenomenon.

KW - Adolescents

KW - Flow-mediated constriction

KW - Flow-mediated dilation

KW - Reactive hyperemia

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=84941173436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941173436&partnerID=8YFLogxK

U2 - 10.1002/jcu.22267

DO - 10.1002/jcu.22267

M3 - Article

VL - 43

SP - 495

EP - 501

JO - Journal of Clinical Ultrasound

JF - Journal of Clinical Ultrasound

SN - 0091-2751

IS - 8

ER -