Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds

Katie M. Minor, Edward E. Patterson, Marguerite K. Keating, Stephanie D. Gross, Kari J. Ekenstedt, Susan M. Taylor, James R. Mickelson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The impact of the mutation causing dynamin 1 (DNM1)-associated exercise-induced collapse (d-EIC) was determined in a retrospective genetic survey. The frequency of DNM1 mutant allele carriers in Labrador retrievers from conformation show, field trial/hunt test, pet or service lines ranged from 17.9% to 38.0% and the frequency of homozygous mutant (EE genotype) individuals ranged from 1.8% to 13.6%; 83.6% of these EE Labradors were reported to have collapsed by 4. years of age.DNM1 mutation carriers and EE dogs with a collapse phenotype were also detected in Chesapeake Bay retrievers, Curly-coated retrievers, Boykin spaniels, Pembroke Welsh corgis and mixed breed dogs thought to be Labrador retriever crosses. The DNM1 mutation was not identified in Golden, Flat-coated, or Nova Scotia duck tolling retrievers, or 15 other non-retrieving breeds. Veterinarians and breeders should be aware that the DNM1 EE genotype is not completely penetrant and that d-EIC is a widespread health concern in several very popular breeds, as well as breeds whose genetic similarity to retrievers is not obvious.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalVeterinary Journal
Volume189
Issue number2
DOIs
StatePublished - Aug 2011

Keywords

  • Canine
  • Dynamin
  • Exercise-induced collapse
  • Inherited disorders
  • Retriever

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