Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations

Jamie Near, Ashley D. Harris, Christoph Juchem, Roland Kreis, Małgorzata Marjańska, Gülin Öz, Johannes Slotboom, Martin Wilson, Charles Gasparovic

Research output: Contribution to journalArticlepeer-review

Abstract

Once an MRS dataset has been acquired, several important steps must be taken to obtain the desired metabolite concentration measures. First, the data must be preprocessed to prepare them for analysis. Next, the intensity of the metabolite signal(s) of interest must be estimated. Finally, the measured metabolite signal intensities must be converted into scaled concentration units employing a quantitative reference signal to allow meaningful interpretation. In this paper, we review these three main steps in the post‐acquisition workflow of a single‐voxel MRS experiment (preprocessing, analysis and quantification) and provide recommendations for best practices at each step.
Original languageEnglish (US)
JournalNMR in biomedicine
DOIs
StatePublished - 2020

PubMed: MeSH publication types

  • Journal Article

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