Preparation of whole rabbit knee joints for microscopic examination

C. Ohrt, M. L. Mahowald, A. A. Valls

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A paraffin embedding method to prepare whole rabbit knee joints for histological examination is described. This method provides good quality microscopic sections thin enough for the study of cellular detail and does not require prolonged processing. When examining pathologic changes in experimental arthritis, it is advantageous to be able to examine the intact joint with the structural relations of the joint components preserved. Sections of the whole joint provide numerous areas where bone, cartilage and synovium are contiguous for examination. Having obtained poor results using methods recommended for small bony specimens, we modified several existing procedures to obtain a reliable method for preparing excellent microscopic sections of the whole rabbit knee joint.

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalBiotechnic and Histochemistry
Issue number6
StatePublished - 1986


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