Dry powder inhalers are often formulated by attaching micronized drug particles onto carrier particles, which are generally lactose. In this study, commercially available lactose was air jet milled to produce unique slab-like coarse carrier particles, which have larger and rougher surfaces compared to other commercially available lactose. Two key processing factors, i.e., classifier speed and jet milling pressure, were systematically investigated. The largest fraction of slab-like particles in the resulting powder was obtained at a classifier speed of 3000 rpm. The slab-like coarse carrier particles are expected to exhibit superior performance than commercial lactose due to their unique surface properties.
Bibliographical noteFunding Information:
The authors would like to thank the funding support for this study from GEA-NUS PPRL (N-148-000-008-001) and SERC Grant No. 102 169 0049 (R-148-000-157-305). Xiang Kou was a recipient of the National University of Singapore Graduate Research Scholarship. Some of the experiments were performed at the University of Minnesota I.T. Characterization Facility, which receives partial support from the NSF through the NNIN program.
- Dry powder inhaler
- Particle engineering
- Shape modification