Preparation of Resin-Bound Bismethylene Cyclic Malonic Acid Ester and Facile Solid-Phase Synthesis of 2-Alkylthio-4(1H)-quinolone and 2-Alkyl-4(1H)-quinolone

Jing Tang, Xian Huang

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10 Scopus citations

Abstract

The resin-bound bismethylthiomethylene cyclic malonic acid ester 3 was built up efficiently. Resin 3 can react with arylamines and subsequent thermal cyclizations give 2-alkylthio-4-(1H)-quinolones. Furthermore, conjugate addition of Grignard reagents to the resin 3 forms the resin 6 which was reacted with aryl amines and subsequent thermal-cyclization-cleavages afford the 2-alkyl-4-(1H)-quinolones.

Original languageEnglish (US)
Pages (from-to)3953-3960
Number of pages8
JournalSynthetic Communications
Volume33
Issue number22
DOIs
StatePublished - 2003

Bibliographical note

Funding Information:
The work was supported by the National Nature Science Foundation of China (Project No. 20072032).

Keywords

  • 2-Alkyl-4-(1H)-quinolones
  • Grignard reagents
  • Resin-bound bismethylthiomethylene cyclic malonic acid ester

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