Preparation of phenolic paclitaxel metabolites

Haeil Park, Michael Hepperle, Thomas C. Boge, Richard H. Himes, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3'-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.

Original languageEnglish (US)
Pages (from-to)2705-2709
Number of pages5
JournalJournal of Medicinal Chemistry
Volume39
Issue number14
DOIs
StatePublished - Jul 5 1996

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