Abstract
A novel route for the conversion of anilides into 3-alkyl-oxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 934-938 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 6 |
| DOIs | |
| State | Published - 2010 |
| Externally published | Yes |
Keywords
- 3-alkyl-oxindoles
- Anilides
- C-H activation
- Copper(II) catalysis
- Cyclisation
- Decarboxyalkylation
- Oxindoles
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