Preparation of 3-alkyl-oxindoles by copper(II)-mediated C-H, Ar-H coupling followed by decarboxyalkylation

David S. Pugh, Johannes E.M.N. Klein, Alexis Perry, Richard J.K. Taylor

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

A novel route for the conversion of anilides into 3-alkyl-oxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.

Original languageEnglish (US)
Pages (from-to)934-938
Number of pages5
JournalSynlett
Issue number6
DOIs
StatePublished - Mar 30 2010

Keywords

  • 3-alkyl-oxindoles
  • Anilides
  • C-H activation
  • Copper(II) catalysis
  • Cyclisation
  • Decarboxyalkylation
  • Oxindoles

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