Preparation and X-ray structural study of 1-arylbenziodoxolones

Mekhman S. Yusubov, Roza Y. Yusubova, Victor N. Nemykin, Viktor Zhdankin

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Various 1-arylbenziodoxolones can be conveniently prepared from 2-iodobenzoic acid and arenes by a one-pot procedure using Oxone (2KHSO 5·KHSO4·K2SO4) as an inexpensive and environmentally safe oxidant. This procedure is also applicable for the synthesis of the 7-methylbenziodoxolone ring system using 2-iodo-3-methylbenzoic acid as starting compound. Structures of four 1-arylbenziodoxolone derivatives were established by single-crystal X-ray diffraction analysis. An enhanced reactivity of 1-aryl-7-methylbenziodoxolones toward nucleophiles compared to unsubstituted 1-arylbenziodoxolones has been found.

Original languageEnglish (US)
Pages (from-to)3767-3773
Number of pages7
JournalJournal of Organic Chemistry
Issue number8
StatePublished - Apr 19 2013


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