Preoperative C-Reactive Protein Levels Predict Readmission Following Elective Vascular Surgery

Asrar Khan, Derrick L. Green, Steve Santilli, Debra K. Johnson, Selma Carlson, Mackenzi Mbai, Rosemary F. Kelly, Amy A. Gravely, Brad Bart, Selcuk Adabag, Santiago Garcia, Qun Chen, Ion S. Jovin, Edward Lesnefsky, Edward O. McFalls

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Background. C-reactive protein (CRP) levels may be reduced with long-term administration of ubiquinone (CoQ10) in patients with chronic ischemic heart disease, but the impact of a short-term period of administration in patients undergoing elective vascular surgery is uncertain. Methods. A double-blind, randomized, controlled trial was implemented to determine whether preoperative administration of CoQ10 could reduce cardiac biomarker elevations. Patients were randomly assigned to CoQ10 (400 mg per day) versus placebo for 3 days prior to surgery. B-type natriuretic peptide (BNP), troponin, and CRP levels were obtained before and after surgery. The primary endpoint was peak biomarker elevations and secondary endpoints were length of stay and readmission. Results. A total of 123 patients were randomly assigned to CoQ10 (n = 62) or placebo (n = 61) for 3 days before surgery. At 24 hours post surgery, the group receiving CoQ10 had lower BNP levels, with no intergroup differences in CRP. Within 1 year post discharge, 36 patients (29%) were readmitted and preoperative risk for readmission included diabetes mellitus (hazard ratio [HR], 3.60; 95% confidence interval [CI], 1.46-8.91), active smoking (HR, 3.55; 95% CI, 1.43-8.78), and CRP (HR, 1.35; 95% CI, 1.04-1.76). C-index for all 3 variables predicting readmission was 0.727. Conclusions. Short-term administration of CoQ10 reduced perioperative BNP, but not CRP levels. CRP, along with diabetes and active smoking, were independent predictors of readmission and might be suitable variables to modify as a means of reducing subsequent rehospitalizations following elective vascular procedures.

Original languageEnglish (US)
Pages (from-to)E39-E44
JournalJournal of Critical Limb Ischemia
Issue number2
StatePublished - Jun 2022

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  • BNP
  • C-reactive protein
  • diabetes mellitus
  • readmissions
  • ubiquinone
  • vascular surgery


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