Preoperative breast MRI and mortality in older women with breast cancer

T. Onega, W. Zhu, J. E. Weiss, M. Goodrich, A. N.A. Tosteson, W. DeMartini, B. A. Virnig, L. M. Henderson, D. S.M. Buist, K. J. Wernli, K. Kerlikowske, R. A. Hubbard

Research output: Contribution to journalArticle

Abstract

Purpose: The survival benefit from detecting additional breast cancers by preoperative magnetic resonance imaging (MRI) continues to be controversial. Methods: We followed a cohort of 4454 women diagnosed with non-metastatic breast cancer (stage I–III) from 2/2005–6/2010 in five registries of the breast cancer surveillance consortium (BCSC). BCSC clinical and registry data were linked to Medicare claims and enrollment data. We estimated the cumulative probability of breast cancer-specific and all-cause mortality. We tested the association of preoperative MRI with all-cause mortality using a Cox proportional hazards model. Results: 917 (20.6%) women underwent preoperative MRI. No significant difference in the cumulative probability of breast cancer-specific mortality was found. We observed no significant difference in the hazard of all-cause mortality during the follow-up period after adjusting for sociodemographic and clinical factors among women with MRI (HR 0.90; 95% CI 0.72–1.12) compared to those without MRI. Conclusion: Our findings of no breast cancer-specific or all-cause mortality benefit supplement prior results that indicate a lack of improvement in surgical outcomes associated with use of preoperative MRI. In combination with other reports, the results of this analysis highlight the importance of exploring the benefit of preoperative MRI in patient-reported outcomes such as women’s decision quality and confidence levels with decisions involving treatment choices.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalBreast Cancer Research and Treatment
Volume170
Issue number1
DOIs
StatePublished - Jul 1 2018

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Keywords

  • Breast cancer
  • Breast cancer mortality
  • Breast cancer treatment
  • Preoperative breast MRI

Cite this

Onega, T., Zhu, W., Weiss, J. E., Goodrich, M., Tosteson, A. N. A., DeMartini, W., Virnig, B. A., Henderson, L. M., Buist, D. S. M., Wernli, K. J., Kerlikowske, K., & Hubbard, R. A. (2018). Preoperative breast MRI and mortality in older women with breast cancer. Breast Cancer Research and Treatment, 170(1), 149-157. https://doi.org/10.1007/s10549-018-4732-z