Increased length of the cavum septum pellucidum (CSP) and in utero infection are each associated with increased risk of schizophrenia. Hence, we examined whether prenatal infections are related to CSP length in schizophrenia patients. In a well-characterized birth cohort, in utero infection was assessed using serologic biomarkers or physician diagnoses. Magnetic resonance images were acquired, and CSP length was quantified by a standard protocol. In utero infection was associated with increased CSP length in exposed schizophrenia cases compared to unexposed cases, suggesting that prenatal infection plays a role in a neurodevelopmental morphologic anomaly that has been related previously to schizophrenia.
Bibliographical noteFunding Information:
Funding for this study was supported by the following grants: R01MH-60249 (A.S. Brown), R01MH-60249 (A.S. Brown), K02-MH65422 (A.S. Brown), NARSAD Independent Investigator Award (A.S. Brown), NICHD N01-HD-1-3334 (B.A. Cohn), NICHD NO1-HD-6-3258 (B.A. Cohn), NIA 1 R01 AG18386 (W.S.K.), R01 AG22381 (W.S. Kremen), and R01 AG22982 (W.S. Kremen). The funding sources had no further role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication.
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