TY - JOUR
T1 - Premorbid psychometric indicators of the gene for Huntington's disease
AU - Lyle, Orcena E.
AU - Gottesman, Irving I.
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Follow-up was made of 88 Ss who had a 50% chance of inheriting Huntington's disease (HD) from a parent and who had been tested 15-20 yrs previously. Striking differences were seen in premorbid mean test scores (Shipley-Institute of Living Scale for Measuring Intellectual Impairment, Bender Visual Motor Gestalt Test, and the Wechsler intelligence tests) between 28 Ss who developed HD and 60 Ss who remained free of HD symptoms. The overall pattern of mean test scores showed progressively lower scores with increased closeness to overt HD. Attempts at "prediction" with test scores were made. Although hit-miss ratios as high as 3 to 1 were found with the intellectual tests, cross-validation could drastically reduce the high prediction accuracy. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).
AB - Follow-up was made of 88 Ss who had a 50% chance of inheriting Huntington's disease (HD) from a parent and who had been tested 15-20 yrs previously. Striking differences were seen in premorbid mean test scores (Shipley-Institute of Living Scale for Measuring Intellectual Impairment, Bender Visual Motor Gestalt Test, and the Wechsler intelligence tests) between 28 Ss who developed HD and 60 Ss who remained free of HD symptoms. The overall pattern of mean test scores showed progressively lower scores with increased closeness to overt HD. Attempts at "prediction" with test scores were made. Although hit-miss ratios as high as 3 to 1 were found with the intellectual tests, cross-validation could drastically reduce the high prediction accuracy. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).
KW - premorbid intelligence test predictors of gene for Huntington's disease, followup of offspring of choreics
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U2 - 10.1037/0022-006X.45.6.1011
DO - 10.1037/0022-006X.45.6.1011
M3 - Article
C2 - 144742
AN - SCOPUS:0017753313
SN - 0022-006X
VL - 45
SP - 1011
EP - 1022
JO - Journal of Consulting Psychology
JF - Journal of Consulting Psychology
IS - 6
ER -