Premorbid psychometric indicators of the gene for Huntington's disease

Orcena E. Lyle, Irving I. Gottesman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Follow-up was made of 88 Ss who had a 50% chance of inheriting Huntington's disease (HD) from a parent and who had been tested 15-20 yrs previously. Striking differences were seen in premorbid mean test scores (Shipley-Institute of Living Scale for Measuring Intellectual Impairment, Bender Visual Motor Gestalt Test, and the Wechsler intelligence tests) between 28 Ss who developed HD and 60 Ss who remained free of HD symptoms. The overall pattern of mean test scores showed progressively lower scores with increased closeness to overt HD. Attempts at "prediction" with test scores were made. Although hit-miss ratios as high as 3 to 1 were found with the intellectual tests, cross-validation could drastically reduce the high prediction accuracy. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)1011-1022
Number of pages12
JournalJournal of Consulting and Clinical Psychology
Volume45
Issue number6
DOIs
StatePublished - Dec 1 1977

Fingerprint

Huntington Disease
Psychometrics
Genes
Bender-Gestalt Test
Intelligence Tests

Keywords

  • premorbid intelligence test predictors of gene for Huntington's disease, followup of offspring of choreics

Cite this

Premorbid psychometric indicators of the gene for Huntington's disease. / Lyle, Orcena E.; Gottesman, Irving I.

In: Journal of Consulting and Clinical Psychology, Vol. 45, No. 6, 01.12.1977, p. 1011-1022.

Research output: Contribution to journalArticle

Lyle, Orcena E. ; Gottesman, Irving I. / Premorbid psychometric indicators of the gene for Huntington's disease. In: Journal of Consulting and Clinical Psychology. 1977 ; Vol. 45, No. 6. pp. 1011-1022.
@article{b8145554d4f54c82b6b8f20428616ffe,
title = "Premorbid psychometric indicators of the gene for Huntington's disease",
abstract = "Follow-up was made of 88 Ss who had a 50{\%} chance of inheriting Huntington's disease (HD) from a parent and who had been tested 15-20 yrs previously. Striking differences were seen in premorbid mean test scores (Shipley-Institute of Living Scale for Measuring Intellectual Impairment, Bender Visual Motor Gestalt Test, and the Wechsler intelligence tests) between 28 Ss who developed HD and 60 Ss who remained free of HD symptoms. The overall pattern of mean test scores showed progressively lower scores with increased closeness to overt HD. Attempts at {"}prediction{"} with test scores were made. Although hit-miss ratios as high as 3 to 1 were found with the intellectual tests, cross-validation could drastically reduce the high prediction accuracy. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).",
keywords = "premorbid intelligence test predictors of gene for Huntington's disease, followup of offspring of choreics",
author = "Lyle, {Orcena E.} and Gottesman, {Irving I.}",
year = "1977",
month = "12",
day = "1",
doi = "10.1037/0022-006X.45.6.1011",
language = "English (US)",
volume = "45",
pages = "1011--1022",
journal = "Journal of Consulting and Clinical Psychology",
issn = "0022-006X",
publisher = "American Psychological Association",
number = "6",

}

TY - JOUR

T1 - Premorbid psychometric indicators of the gene for Huntington's disease

AU - Lyle, Orcena E.

AU - Gottesman, Irving I.

PY - 1977/12/1

Y1 - 1977/12/1

N2 - Follow-up was made of 88 Ss who had a 50% chance of inheriting Huntington's disease (HD) from a parent and who had been tested 15-20 yrs previously. Striking differences were seen in premorbid mean test scores (Shipley-Institute of Living Scale for Measuring Intellectual Impairment, Bender Visual Motor Gestalt Test, and the Wechsler intelligence tests) between 28 Ss who developed HD and 60 Ss who remained free of HD symptoms. The overall pattern of mean test scores showed progressively lower scores with increased closeness to overt HD. Attempts at "prediction" with test scores were made. Although hit-miss ratios as high as 3 to 1 were found with the intellectual tests, cross-validation could drastically reduce the high prediction accuracy. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

AB - Follow-up was made of 88 Ss who had a 50% chance of inheriting Huntington's disease (HD) from a parent and who had been tested 15-20 yrs previously. Striking differences were seen in premorbid mean test scores (Shipley-Institute of Living Scale for Measuring Intellectual Impairment, Bender Visual Motor Gestalt Test, and the Wechsler intelligence tests) between 28 Ss who developed HD and 60 Ss who remained free of HD symptoms. The overall pattern of mean test scores showed progressively lower scores with increased closeness to overt HD. Attempts at "prediction" with test scores were made. Although hit-miss ratios as high as 3 to 1 were found with the intellectual tests, cross-validation could drastically reduce the high prediction accuracy. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

KW - premorbid intelligence test predictors of gene for Huntington's disease, followup of offspring of choreics

UR - http://www.scopus.com/inward/record.url?scp=0017753313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017753313&partnerID=8YFLogxK

U2 - 10.1037/0022-006X.45.6.1011

DO - 10.1037/0022-006X.45.6.1011

M3 - Article

VL - 45

SP - 1011

EP - 1022

JO - Journal of Consulting and Clinical Psychology

JF - Journal of Consulting and Clinical Psychology

SN - 0022-006X

IS - 6

ER -