Preliminary observations of paranoia in a human laboratory study of cocaine

Marc Mooney; Mehmet Sofuoglu; Susan Dudish-Poulsen; Dorothy K. Hatsukami

doi:10.1016/j.addbeh.2005.08.003

Preliminary observations of paranoia in a human laboratory study of cocaine

Marc Mooney
, Mehmet Sofuoglu
, Susan Dudish-Poulsen
, Dorothy K. Hatsukami

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.

Original language	English (US)
Pages (from-to)	1245-1251
Number of pages	7
Journal	Addictive Behaviors
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.addbeh.2005.08.003
State	Published - Jul 2006

Bibliographical note

Funding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cocaine-induced paranoia
Crack-cocaine
Gender differences

Publisher link

10.1016/j.addbeh.2005.08.003

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title = "Preliminary observations of paranoia in a human laboratory study of cocaine",

abstract = "Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67\%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.",

keywords = "Cocaine-induced paranoia, Crack-cocaine, Gender differences",

author = "Marc Mooney and Mehmet Sofuoglu and Susan Dudish-Poulsen and Hatsukami, \{Dorothy K.\}",

note = "Funding Information: This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400).",

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AU - Mooney, Marc

AU - Sofuoglu, Mehmet

AU - Dudish-Poulsen, Susan

AU - Hatsukami, Dorothy K.

N1 - Funding Information: This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400).

PY - 2006/7

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N2 - Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.

AB - Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.

KW - Cocaine-induced paranoia

KW - Crack-cocaine

KW - Gender differences

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AN - SCOPUS:33745184209

SN - 0306-4603

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Preliminary observations of paranoia in a human laboratory study of cocaine

Abstract

Bibliographical note

UN SDGs

Keywords

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