Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.
Bibliographical noteFunding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400).
- Cocaine-induced paranoia
- Gender differences