Preliminary observations of paranoia in a human laboratory study of cocaine

Marc Mooney, Mehmet Sofuoglu, Susan Dudish-Poulsen, Dorothy K. Hatsukami

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32 Scopus citations


Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.

Original languageEnglish (US)
Pages (from-to)1245-1251
Number of pages7
JournalAddictive Behaviors
Issue number7
StatePublished - Jul 2006

Bibliographical note

Funding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400).


  • Cocaine-induced paranoia
  • Crack-cocaine
  • Gender differences


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