Prefrontal NIRS signal is unaffected by forehead Doppler flux during incremental cycling exercise

Research output: Contribution to journalArticlepeer-review

Abstract

Near-infrared spectroscopy (NIRS) is used to measure tissue concentrations of oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb). In the context of exercise, NIRS confers a higher signal-to-noise ratio than other neuroimaging techniques. However, part of the signal may be influenced by thermoregulatory hyperemia in the superficial cutaneous capillaries of the forehead. The degree to which NIRS signals during exercise reflect cerebral or extracerebral hemodynamic changes is a continuing source of controversy. However, the influence of skin blood flow may be attenuated depending on the NIRS technique (e.g., frequency domain machines with maximal optode separation distances >3.5 cm). The purpose of this study was to compare the changes in forehead skin blood flow and cerebral hemoglobin concentration during incremental exercise versus direct vasodilation of the forehead skin induced by gradual local heating. Thirty participants (12 females, 18 males; age: 20.8 ± 3.2 years; body mass index: 23.8 ± 3.7 kg·m−2) participated in the study. Forehead skin blood flow was quantified laser Doppler flux and absolute concentrations of cerebral O2Hb and HHb were measured by NIRS. Local heating significantly increased the Doppler flux signal across time and these changes were significantly correlated with skin temperature. During incremental exercise, skin temperature, Doppler flux, O2Hb and HHb increased however, the only significant change that was consistently correlated with Doppler flux was skin temperature. Therefore, a significant change in forehead skin blood flow may not significantly the NIRS hemoglobin data, depending on the type of NIRS device used.

Original languageEnglish (US)
Pages (from-to)393-403
Number of pages11
JournalClinical Physiology and Functional Imaging
Volume43
Issue number6
DOIs
StatePublished - Nov 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Scandinavian Society of Clinical Physiology and Nuclear Medicine.

Keywords

  • hemodynamics
  • physical activity
  • prefrontal cortex
  • skin blood flow

PubMed: MeSH publication types

  • Journal Article

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