Prefrontal functioning during context processing in schizophrenia and major depression: An event-related fMRI study

Avram J. Holmes; Angus MacDonald; Cameron S. Carter; Deanna M. Barch; V. Andrew Stenger; Jonathan D. Cohen

doi:10.1016/j.schres.2005.01.021

Prefrontal functioning during context processing in schizophrenia and major depression: An event-related fMRI study

Avram J. Holmes, Angus MacDonald, Cameron S. Carter, Deanna M. Barch, V. Andrew Stenger, Jonathan D. Cohen

Psychology (Twin Cities)

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Patients with schizophrenia frequently demonstrate hypofrontality in tasks that require executive processing; however questions still remain as to whether prefrontal cortex dysfunctions are specific to schizophrenia, or a general feature of major psychopathology. Context processing is conceptualized as an executive function associated with attention and working memory processes. Impairment in the ability of patients with schizophrenia to represent and maintain context information has been previously reported in a number of studies. To examine the question of the specificity of a context processing deficit to schizophrenia, we used functional MRI and an expectancy AX continuous performance task designed to assess context processing in a group of healthy controls (n = 9), depressed patient controls (n = 10), and patients with schizophrenia (n = 7). The behavioral performance was consistent with a context processing deficit in patients with schizophrenia, but not those with depression. The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing.

Original language	English (US)
Pages (from-to)	199-206
Number of pages	8
Journal	Schizophrenia Research
Volume	76
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2005.01.021
State	Published - Jul 15 2005

Bibliographical note

Funding Information:
We are grateful to Howard Aizenstein, MD, Greg Siegle, PhD, Kristi Clark, BS, Grace Nah, BA, and Greg Nickliss, BA, and the UPMC Magnetic Resonance Research Center for their invaluable assistance in the conduct of this study. Results from this study were presented at the 9th Annual International Congress of Schizophrenia Research, Colorado Springs, CO. This work was supported by NIMH Grants #MH47073 and MH59883 and Dr. MacDonald was supported by NIMH Grant #T32 MH18269.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Context processing
Functional MRI
Hypofrontality
Major depression
Prefrontal Cortex
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.schres.2005.01.021

Find It

Find It at U of M Libraries

Cite this

@article{9d82b9674d1448a2861bd2061bd3a593,

title = "Prefrontal functioning during context processing in schizophrenia and major depression: An event-related fMRI study",

abstract = "Patients with schizophrenia frequently demonstrate hypofrontality in tasks that require executive processing; however questions still remain as to whether prefrontal cortex dysfunctions are specific to schizophrenia, or a general feature of major psychopathology. Context processing is conceptualized as an executive function associated with attention and working memory processes. Impairment in the ability of patients with schizophrenia to represent and maintain context information has been previously reported in a number of studies. To examine the question of the specificity of a context processing deficit to schizophrenia, we used functional MRI and an expectancy AX continuous performance task designed to assess context processing in a group of healthy controls (n = 9), depressed patient controls (n = 10), and patients with schizophrenia (n = 7). The behavioral performance was consistent with a context processing deficit in patients with schizophrenia, but not those with depression. The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing.",

keywords = "Context processing, Functional MRI, Hypofrontality, Major depression, Prefrontal Cortex, Schizophrenia",

author = "Holmes, {Avram J.} and Angus MacDonald and Carter, {Cameron S.} and Barch, {Deanna M.} and Stenger, {V. Andrew} and Cohen, {Jonathan D.}",

note = "Funding Information: We are grateful to Howard Aizenstein, MD, Greg Siegle, PhD, Kristi Clark, BS, Grace Nah, BA, and Greg Nickliss, BA, and the UPMC Magnetic Resonance Research Center for their invaluable assistance in the conduct of this study. Results from this study were presented at the 9th Annual International Congress of Schizophrenia Research, Colorado Springs, CO. This work was supported by NIMH Grants #MH47073 and MH59883 and Dr. MacDonald was supported by NIMH Grant #T32 MH18269. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2005",

month = jul,

day = "15",

doi = "10.1016/j.schres.2005.01.021",

language = "English (US)",

volume = "76",

pages = "199--206",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - Prefrontal functioning during context processing in schizophrenia and major depression

T2 - An event-related fMRI study

AU - Holmes, Avram J.

AU - MacDonald, Angus

AU - Carter, Cameron S.

AU - Barch, Deanna M.

AU - Stenger, V. Andrew

AU - Cohen, Jonathan D.

N1 - Funding Information: We are grateful to Howard Aizenstein, MD, Greg Siegle, PhD, Kristi Clark, BS, Grace Nah, BA, and Greg Nickliss, BA, and the UPMC Magnetic Resonance Research Center for their invaluable assistance in the conduct of this study. Results from this study were presented at the 9th Annual International Congress of Schizophrenia Research, Colorado Springs, CO. This work was supported by NIMH Grants #MH47073 and MH59883 and Dr. MacDonald was supported by NIMH Grant #T32 MH18269. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2005/7/15

Y1 - 2005/7/15

N2 - Patients with schizophrenia frequently demonstrate hypofrontality in tasks that require executive processing; however questions still remain as to whether prefrontal cortex dysfunctions are specific to schizophrenia, or a general feature of major psychopathology. Context processing is conceptualized as an executive function associated with attention and working memory processes. Impairment in the ability of patients with schizophrenia to represent and maintain context information has been previously reported in a number of studies. To examine the question of the specificity of a context processing deficit to schizophrenia, we used functional MRI and an expectancy AX continuous performance task designed to assess context processing in a group of healthy controls (n = 9), depressed patient controls (n = 10), and patients with schizophrenia (n = 7). The behavioral performance was consistent with a context processing deficit in patients with schizophrenia, but not those with depression. The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing.

AB - Patients with schizophrenia frequently demonstrate hypofrontality in tasks that require executive processing; however questions still remain as to whether prefrontal cortex dysfunctions are specific to schizophrenia, or a general feature of major psychopathology. Context processing is conceptualized as an executive function associated with attention and working memory processes. Impairment in the ability of patients with schizophrenia to represent and maintain context information has been previously reported in a number of studies. To examine the question of the specificity of a context processing deficit to schizophrenia, we used functional MRI and an expectancy AX continuous performance task designed to assess context processing in a group of healthy controls (n = 9), depressed patient controls (n = 10), and patients with schizophrenia (n = 7). The behavioral performance was consistent with a context processing deficit in patients with schizophrenia, but not those with depression. The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing.

KW - Context processing

KW - Functional MRI

KW - Hypofrontality

KW - Major depression

KW - Prefrontal Cortex

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=20444386562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444386562&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2005.01.021

DO - 10.1016/j.schres.2005.01.021

M3 - Article

C2 - 15949653

AN - SCOPUS:20444386562

SN - 0920-9964

VL - 76

SP - 199

EP - 206

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Prefrontal functioning during context processing in schizophrenia and major depression: An event-related fMRI study

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this