Preferential localization of effector memory cells in nonlymphoid tissue

D. Masopust, V. Vezys, A. L. Marzo, L. Lefrançois

Research output: Contribution to journalArticlepeer-review

1447 Scopus citations

Abstract

Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.

Original languageEnglish (US)
Pages (from-to)2413-2417
Number of pages5
JournalScience
Volume291
Issue number5512
DOIs
StatePublished - Mar 23 2001

Bibliographical note

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

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