Preferential localization of effector memory cells in nonlymphoid tissue

D. Masopust, V. Vezys, A. L. Marzo, L. Lefrançois

Research output: Contribution to journalArticlepeer-review

1447 Scopus citations


Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.

Original languageEnglish (US)
Pages (from-to)2413-2417
Number of pages5
Issue number5512
StatePublished - Mar 23 2001

Bibliographical note

Copyright 2007 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'Preferential localization of effector memory cells in nonlymphoid tissue'. Together they form a unique fingerprint.

Cite this