Predictors of telomere content in dragon lizards

Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, Mats Olsson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Telomeres shorten as a consequence of DNA replication, in particular in cells with low production of telomerase and perhaps in response to physiological stress from exposure to reactive oxygen species, such as superoxide. This process of telomere attrition is countered by innate antioxidation, such as via the production of superoxide dismutase. We studied the inheritance of telomere length in the Australian painted dragon lizard (Ctenophorus pictus) and the extent to which telomere length covaries with masscorrected maternal reproductive investment, which reflects the level of circulating yolk precursor and antioxidant, vitellogenin. Our predictors of offspring telomere length explained 72 % of telomere variation (including interstitial telomeres if such are present). Maternal telomere length and reproductive investment were positively influencing offspring telomere length in our analyses, whereas flow cytometry-estimated superoxide level was negatively impacting offspring telomere length. We suggest that the effects of superoxide on hatchling telomere shortening may be partly balanced by transgenerational effects of vitellogenin antioxidation.

Original languageEnglish (US)
Pages (from-to)661-664
Number of pages4
JournalNaturwissenschaften
Volume99
Issue number8
DOIs
StatePublished - Aug 1 2012

Fingerprint

telomeres
lizard
lizards
flow cytometry
antioxidant
DNA
superoxide anion
vitellogenin
effect
telomerase
DNA replication
shortenings
reactive oxygen species
inheritance (genetics)
superoxide dismutase
exposure
antioxidants

Keywords

  • Lizard
  • Reactive oxygen species
  • Superoxide
  • Telomere
  • Vitellogenin

Cite this

Ballen, C., Healey, M., Wilson, M., Tobler, M., & Olsson, M. (2012). Predictors of telomere content in dragon lizards. Naturwissenschaften, 99(8), 661-664. https://doi.org/10.1007/s00114-012-0941-1

Predictors of telomere content in dragon lizards. / Ballen, Cissy; Healey, Mo; Wilson, Mark; Tobler, Michael; Olsson, Mats.

In: Naturwissenschaften, Vol. 99, No. 8, 01.08.2012, p. 661-664.

Research output: Contribution to journalArticle

Ballen, C, Healey, M, Wilson, M, Tobler, M & Olsson, M 2012, 'Predictors of telomere content in dragon lizards', Naturwissenschaften, vol. 99, no. 8, pp. 661-664. https://doi.org/10.1007/s00114-012-0941-1
Ballen C, Healey M, Wilson M, Tobler M, Olsson M. Predictors of telomere content in dragon lizards. Naturwissenschaften. 2012 Aug 1;99(8):661-664. https://doi.org/10.1007/s00114-012-0941-1
Ballen, Cissy ; Healey, Mo ; Wilson, Mark ; Tobler, Michael ; Olsson, Mats. / Predictors of telomere content in dragon lizards. In: Naturwissenschaften. 2012 ; Vol. 99, No. 8. pp. 661-664.
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