Abstract
Background: Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited. Methods: We conducted a retrospective review of the National Cancer Database. Results: Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with high-grade histology (67.2%). Regional metastasis was common (35.9%), whereas occult nodal metastasis (20.2% overall) was less frequent in non-high-grade lesions (8.5% vs 31.6%; p <.001). Distant metastasis was rare (7.9%). Five-year overall survival (OS) was 47%. In multivariate analysis, age, regional metastasis, distant metastasis, high-grade, and T classification were predictors of lower survival. Patients with stage III to IV disease receiving surgery and radiotherapy had a better OS than those receiving surgery alone (51% vs 41%; p <.001). Conclusion: PANOS is an aggressive disease with frequent regional metastasis and low survival. Numerous variables are associated with worse survival.
Original language | English (US) |
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Pages (from-to) | 1208-1212 |
Number of pages | 5 |
Journal | Head and Neck |
Volume | 38 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Wiley Periodicals, Inc.
Keywords
- adenocarcinoma
- cancer
- malignancy
- parotid glands
- salivary gland
- survival
- tumor