Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

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OBJECTIVE: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.

DESIGN: Retrospective study.

SETTING: Midwest hospital health system.

PARTICIPANTS: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.

INTERVENTION: Not applicable.

MAIN OUTCOME MEASURES: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.

RESULTS: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).

CONCLUSIONS: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.

Original languageEnglish (US)
JournalArchives of Physical Medicine and Rehabilitation
StateAccepted/In press - 2022

Bibliographical note

Funding Information:
Supported by the National Institutes of Health's National Center for Advancing Translational Sciences grant no. U01TR002062.

Publisher Copyright:
© 2022 The Authors


  • COVID-19
  • Function
  • Rehabilitation


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