Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Nermine Abdelwahab; Nicholas E. Ingraham; Nguyen Nguyen; Lianne Siegel; Greg Silverman; Himanshu Shekhar Sahoo; Serguei Pakhomov; Leslie R. Morse; Joanne Billings; Michael G. Usher; Tanya E. Melnik; Christopher J. Tignanelli; Farha Ikramuddin

doi:10.1016/j.apmr.2022.04.009

Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Nermine Abdelwahab, Nicholas E. Ingraham, Nguyen Nguyen, Lianne Siegel, Greg Silverman, Himanshu Shekhar Sahoo, Serguei Pakhomov, Leslie R. Morse, Joanne Billings, Michael G. Usher, Tanya E. Melnik, Christopher J. Tignanelli, Farha Ikramuddin

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7 Scopus citations

Abstract

OBJECTIVE: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.

DESIGN: Retrospective study.

SETTING: Midwest hospital health system.

PARTICIPANTS: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.

INTERVENTION: Not applicable.

MAIN OUTCOME MEASURES: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.

RESULTS: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).

CONCLUSIONS: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.

Original language	English (US)
Pages (from-to)	2001-2008
Number of pages	8
Journal	Archives of Physical Medicine and Rehabilitation
Volume	103
Issue number	10
DOIs	https://doi.org/10.1016/j.apmr.2022.04.009
State	Published - Oct 2022

Bibliographical note

Funding Information:
Supported by the National Institutes of Health's National Center for Advancing Translational Sciences grant no. U01TR002062.

Publisher Copyright:
© 2022 The Authors

Keywords

COVID-19
Function
Rehabilitation
SARS-CoV-2
COVID-19/epidemiology
Angiotensin-Converting Enzyme Inhibitors
Humans
Angiotensins
Adult
Male
Retrospective Studies

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.apmr.2022.04.009

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Abdelwahab, N., Ingraham, N. E., Nguyen, N., Siegel, L., Silverman, G., Sahoo, H. S., Pakhomov, S., Morse, L. R., Billings, J., Usher, M. G., Melnik, T. E., Tignanelli, C. J., & Ikramuddin, F. (2022). Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study. Archives of Physical Medicine and Rehabilitation, 103(10), 2001-2008. https://doi.org/10.1016/j.apmr.2022.04.009

Abdelwahab, N, Ingraham, NE , Nguyen, N, Siegel, L, Silverman, G, Sahoo, HS, Pakhomov, S, Morse, LR, Billings, J , Usher, MG , Melnik, TE , Tignanelli, CJ & Ikramuddin, F 2022, 'Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study', Archives of Physical Medicine and Rehabilitation, vol. 103, no. 10, pp. 2001-2008. https://doi.org/10.1016/j.apmr.2022.04.009

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title = "Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study",

abstract = "OBJECTIVE: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.DESIGN: Retrospective study.SETTING: Midwest hospital health system.PARTICIPANTS: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.INTERVENTION: Not applicable.MAIN OUTCOME MEASURES: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.RESULTS: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).CONCLUSIONS: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.",

keywords = "COVID-19, Function, Rehabilitation, SARS-CoV-2, COVID-19/epidemiology, Angiotensin-Converting Enzyme Inhibitors, Humans, Angiotensins, Adult, Male, Retrospective Studies",

author = "Nermine Abdelwahab and Ingraham, {Nicholas E.} and Nguyen Nguyen and Lianne Siegel and Greg Silverman and Sahoo, {Himanshu Shekhar} and Serguei Pakhomov and Morse, {Leslie R.} and Joanne Billings and Usher, {Michael G.} and Melnik, {Tanya E.} and Tignanelli, {Christopher J.} and Farha Ikramuddin",

note = "Funding Information: Supported by the National Institutes of Health's National Center for Advancing Translational Sciences grant no. U01TR002062. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = oct,

doi = "10.1016/j.apmr.2022.04.009",

language = "English (US)",

volume = "103",

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journal = "Archives of Physical Medicine and Rehabilitation",

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T1 - Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation

T2 - A Retrospective Study

AU - Abdelwahab, Nermine

AU - Ingraham, Nicholas E.

AU - Nguyen, Nguyen

AU - Siegel, Lianne

AU - Silverman, Greg

AU - Sahoo, Himanshu Shekhar

AU - Pakhomov, Serguei

AU - Morse, Leslie R.

AU - Billings, Joanne

AU - Usher, Michael G.

AU - Melnik, Tanya E.

AU - Tignanelli, Christopher J.

AU - Ikramuddin, Farha

PY - 2022/10

Y1 - 2022/10

N2 - OBJECTIVE: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.DESIGN: Retrospective study.SETTING: Midwest hospital health system.PARTICIPANTS: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.INTERVENTION: Not applicable.MAIN OUTCOME MEASURES: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.RESULTS: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).CONCLUSIONS: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.

AB - OBJECTIVE: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.DESIGN: Retrospective study.SETTING: Midwest hospital health system.PARTICIPANTS: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.INTERVENTION: Not applicable.MAIN OUTCOME MEASURES: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.RESULTS: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).CONCLUSIONS: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.

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KW - Function

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KW - SARS-CoV-2

KW - COVID-19/epidemiology

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Humans

KW - Angiotensins

KW - Adult

KW - Male

KW - Retrospective Studies

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Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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