Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


OBJECTIVE: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.

DESIGN: Retrospective study.

SETTING: Midwest hospital health system.

PARTICIPANTS: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.

INTERVENTION: Not applicable.

MAIN OUTCOME MEASURES: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.

RESULTS: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).

CONCLUSIONS: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.

Original languageEnglish (US)
Pages (from-to)2001-2008
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Issue number10
StatePublished - Oct 2022

Bibliographical note

Funding Information:
Supported by the National Institutes of Health's National Center for Advancing Translational Sciences grant no. U01TR002062.

Publisher Copyright:
© 2022 The Authors


  • COVID-19
  • Function
  • Rehabilitation
  • SARS-CoV-2
  • COVID-19/epidemiology
  • Angiotensin-Converting Enzyme Inhibitors
  • Humans
  • Angiotensins
  • Adult
  • Male
  • Retrospective Studies

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural


Dive into the research topics of 'Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study'. Together they form a unique fingerprint.

Cite this