Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation

Alik S. Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R. Arulpragasam, Joan A. Camprodon, Cristina Cusin, Emad N. Eskandar, Thilo Deckersbach, Darin D. Dougherty

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
StatePublished - Dec 1 2016
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by a Picower Family Foundation grant to Dr. Widge; NIMH(National Institute of Mental Health) grant MH076179 to Drs. Eskandar and Dougherty; University of California, San Diego Division of Geriatric Psychiatry M-STREAM program support to Dr. Licon; and Defense Advanced Research Projects Agency Cooperative Agreement W911NF-14-2-0045 to Drs. Widge, Zorowitz, Arulpragasam, Eskandar, Deckersbach, and Dougherty. The underlying clinical trials were supported through Medtronic and NIMH. The funding sources for this research had no direct role in the study design, analysis, or publication. The opinions expressed herein are those of the authors, not their funding agencies.

Publisher Copyright:
© 2016, American Psychiatric Association. All rights reserved.


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