Abstract
The purpose of this study was to examine the predictors of heart rate and blood pressure changes following cocaine administration. Sixty-two smoked cocaine users received a single 0.4 mg/kg dose of smoked cocaine. Male sex, African-American race, higher body weight and current marijuana use predicted a greater cardiovascular response to cocaine. In contrast, higher baseline blood pressure, heart rate, amount and frequency of current cocaine use and presence of current cocaine snorting predicted a diminished cardiovascular response to cocaine. Whether these predictors of the cardiovascular response to smoked cocaine in the laboratory also predict cardiovascular complications from long-term cocaine use needs to be studied further. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-245 |
| Number of pages | 7 |
| Journal | Drug and alcohol dependence |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2000 |
Bibliographical note
Funding Information:This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). The authors would like to thank David Babb and the General Clinical Research Center nursing staff for technical assistance.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Blood pressure
- Cardiovascular response
- Cocaine
- Crack cocaine
- Heart rate
- Toxicity
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