Abstract
The purpose of this study was to examine the predictors of heart rate and blood pressure changes following cocaine administration. Sixty-two smoked cocaine users received a single 0.4 mg/kg dose of smoked cocaine. Male sex, African-American race, higher body weight and current marijuana use predicted a greater cardiovascular response to cocaine. In contrast, higher baseline blood pressure, heart rate, amount and frequency of current cocaine use and presence of current cocaine snorting predicted a diminished cardiovascular response to cocaine. Whether these predictors of the cardiovascular response to smoked cocaine in the laboratory also predict cardiovascular complications from long-term cocaine use needs to be studied further. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-245 |
| Number of pages | 7 |
| Journal | Drug and alcohol dependence |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2000 |
Bibliographical note
Funding Information:This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). The authors would like to thank David Babb and the General Clinical Research Center nursing staff for technical assistance.
Keywords
- Blood pressure
- Cardiovascular response
- Cocaine
- Crack cocaine
- Heart rate
- Toxicity
