Predictors of calcium retention in adolescent boys

Kathleen M. Hill, Michelle M Braun, Mark Kern, Berdine R. Martin, James W. Navalta, Darlene A. Sedlock, Linda McCabe, George P. McCabe, Munro Peacock, Connie M. Weaver

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

CONTEXT: The relationship between calcium (Ca) intake and Ca retention in adolescent boys was recently reported.

OBJECTIVE: This study evaluated the influence of Ca intake, serum hormone levels, biomarkers of bone metabolism, habitual physical activity, habitual Ca intake, and physical fitness on Ca retention in the same sample.

DESIGN: This study was a randomized, cross-over design that consisted of two 3-wk metabolic balance periods.

SETTING: The study took place on a university campus as a summer camp.

PATIENTS OR OTHER PARTICIPANTS: A total of 31 American white boys (13-15 yr) participated in the study.

INTERVENTIONS: Each subject consumed a controlled diet with one of five high-low Ca intake pairs that ranged from 670-2003 mg/d, which was manipulated utilizing a fortified beverage.

MAIN OUTCOME MEASURES: Ca retention was determined by Ca intake minus urinary and fecal Ca excretion during each balance period.

RESULTS: Ca intake explained 21.7% of the variability in Ca retention, and serum IGF-I concentration explained an additional 11.5%. Other serum hormone levels did not significantly add to the model. Biomarkers of bone metabolism, habitual physical activity, habitual Ca intake, and physical fitness were not significant predictors of Ca retention in adolescent boys.

CONCLUSIONS: IGF-I, a regulator of growth during puberty, is an important predictor of Ca retention in adolescent boys. However, dietary Ca intake is an even greater predictor of Ca retention during this period of growth.

Original languageEnglish (US)
Pages (from-to)4743-4748
Number of pages6
JournalThe Journal of clinical endocrinology and metabolism
Volume93
Issue number12
DOIs
StatePublished - Dec 2008

Keywords

  • Adolescent
  • Anthropometry
  • Beverages
  • Biomarkers
  • Bone and Bones/metabolism
  • Calcium/metabolism
  • Calcium, Dietary/metabolism
  • Diet
  • Double-Blind Method
  • Feces/chemistry
  • Feeding Behavior
  • Habits
  • Hormones/blood
  • Humans
  • Insulin-Like Growth Factor I/metabolism
  • Life Style
  • Male
  • Motor Activity/physiology
  • Physical Fitness
  • Predictive Value of Tests

PubMed: MeSH publication types

  • Journal Article
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

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