Predictors of 30-day post-transplant mortality in patients bridged to transplantation with continuous-flow left ventricular assist devices - An analysis of the International Society for Heart and Lung Transplantation Transplant Registry

Aaron H. Healy, Josef Stehlik, Leah B. Edwards, Stephen H. McKellar, Stavros G. Drakos, Craig H. Selzman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background Continuous-flow (CF) left ventricular assist devices (LVADs) are standard of care for bridging patients to cardiac transplantation. However, existing data about preoperative factors influencing early post-transplant survival in these patients are limited. We sought to determine risk factors for mortality using a large international database. Methods All patients in the International Society for Heart and Lung Transplantation Transplant Registry who were bridged to transplantation with CF LVADs between June 2008 and June 2012 were included. Risk factors for mortality within 30 days of transplant were identified. Statistical analysis included multivariable analysis and Kaplan-Meier survival analysis. Results During the study period, 2,152 patients with CF LVADs underwent heart transplantation. Post-transplant survival was 95.5% at 30 days. Risk factors for mortality during this window included ventilator support at transplant (hazard ratio [HR] = 5.00, 95% confidence interval [CI] = 1.51-16.58), female recipient/male donor (compared with all other combinations, HR = 3.29, 95% CI = 1.90-5.72), history of hemodialysis (HR = 2.51, 95% CI = 1.14-5.51), and history of coronary bypass grafting (HR = 1.89, 95% CI = 1.19-3.00). Increasing recipient age (p = 0.002), body mass index (p = 0.002), creatinine (p = 0.004), and total bilirubin (p < 0.001) also were associated with an increase in mortality. Conclusions In patients supported with CF LVADs, risk factors for early mortality can be identified before transplant, including ventilator support, female recipient/male donor, increasing recipient age, and body mass index. Despite the inherent complexities of a reoperative surgery, patients bridged to transplant with CF LVADs have excellent peri-operative survival.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2016

Bibliographical note

Funding Information:
A.H.H. received funding from a 2013 International Society of Heart and Lung Transplantation Transplant Registry Early Career Award. None of the authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose. This work was presented at the 34th Annual Meeting of the International Society of Heart and Lung Transplantation, San Diego, California, April 12, 2014.

Publisher Copyright:
© 2016 International Society for Heart and Lung Transplantation.

Keywords

  • bridge to transplant
  • continuous flow
  • outcomes
  • transplantation
  • ventricular assist device

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