Predictive associations of music, anxiety, and sedative exposure on mechanical ventilation weaning trials

Breanna Hetland, Ruth Lindquist, Craig R. Weinert, Cynthia Peden-McAlpine, Kay Savik, Linda Chlan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background Weaning from mechanical ventilation requires increased respiratory effort, which can heighten anxiety and later prolong the need for mechanical ventilation. Objectives To examine the predictive associations of music intervention, anxiety, sedative exposure, and patients' characteristics on time to initiation and duration of weaning trials of patients receiving mechanical ventilation. Methods A descriptive, correlational design was used for a secondary analysis of data from a randomized trial. Music listening was defined as self-initiated, patient-directed music via headphones. Anxiety was measured daily with a visual analog scale. Sedative exposure was operationalized as a daily sedation intensity score and a sedative dose frequency. Analyses consisted of descriptive statistics, graphing, survival analysis, Cox proportional hazards regression, and linear regression. Results Of 307 patients, 52% were women and 86% were white. Mean age was 59.3 (SD, 14.4) years, mean Acute Physiology and Chronic Health Evaluation III score was 62.9 (SD, 21.6), mean duration of ventilatory support was 8 (range, 1-52) days, and mean stay in the intensive care unit was 18 (range, 2-71) days. Music listening, anxiety levels, and sedative exposure did not influence time to initial weaning trial or duration of trials. Clinical factors of illness severity, days of weaning trials, and tracheostomy placement influenced weaning patterns in this sample. Conclusions Prospective studies of music intervention and other psychophysiological factors during weaning from mechanical ventilation are needed to better understand factors that promote successful weaning.

Original languageEnglish (US)
Pages (from-to)210-220
Number of pages11
JournalAmerican Journal of Critical Care
Issue number3
StatePublished - May 1 2017

Bibliographical note

Funding Information:
FINANCIAL DISCLOSURES This research was supported by the National Institute of Nursing Research of the National Institutes of Health (Award no. F31-NR014591).

Publisher Copyright:
© 2017 American Association of Critical-Care Nurses.

Copyright 2017 Elsevier B.V., All rights reserved.


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