Prediction of in-hospital mortality after ruptured abdominal aortic aneurysm repair using an artificial neural network

Eric S. Wise, Kyle M. Hocking, Colleen M. Brophy

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Objective Ruptured abdominal aortic aneurysm (rAAA) carries a high mortality rate, even with prompt transfer to a medical center. An artificial neural network (ANN) is a computational model that improves predictive ability through pattern recognition while continually adapting to new input data. The goal of this study was to effectively use ANN modeling to provide vascular surgeons a discriminant adjunct to assess the likelihood of in-hospital mortality on a pending rAAA admission using easily obtainable patient information from the field. Methods Of 332 total patients from a single institution from 1998 to 2013 who had attempted rAAA repair, 125 were reviewed for preoperative factors associated with in-hospital mortality; 108 patients received an open operation, and 17 patients received endovascular repair. Five variables were found significant on multivariate analysis (P <.05), and four of these five (preoperative shock, loss of consciousness, cardiac arrest, and age) were modeled by multiple logistic regression and an ANN. These predictive models were compared against the Glasgow Aneurysm Score. All models were assessed by generation of receiver operating characteristic curves and actual vs predicted outcomes plots, with area under the curve and Pearson r2 value as the primary measures of discriminant ability. Results Of the 125 patients, 53 (42%) did not survive to discharge. Five preoperative factors were significant (P <.05) independent predictors of in-hospital mortality in multivariate analysis: advanced age, renal disease, loss of consciousness, cardiac arrest, and shock, although renal disease was excluded from the models. The sequential accumulation of zero to four of these risk factors progressively increased overall mortality rate, from 11% to 16% to 44% to 76% to 89% (age ≥ 70 years considered a risk factor). Algorithms derived from multiple logistic regression, ANN, and Glasgow Aneurysm Score models generated area under the curve values of 0.85 ± 0.04, 0.88 ± 0.04 (training set), and 0.77 ± 0.06 and Pearson r2 values of.36,.52 and.17, respectively. The ANN model represented the most discriminant of the three. Conclusions An ANN-based predictive model may represent a simple, useful, and highly discriminant adjunct to the vascular surgeon in accurately identifying those patients who may carry a high mortality risk from attempted repair of rAAA, using only easily definable preoperative variables. Although still requiring external validation, our model is available for demonstration at https://redcap.vanderbilt.edu/surveys/?s=NN97NM7DTK.

Original languageEnglish (US)
Article number7942
Pages (from-to)8-15
Number of pages8
JournalJournal of vascular surgery
Volume62
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Bibliographical note

Funding Information:
Grant support: Vanderbilt REDCap; Clinical and Translational Science Award UL1 TR000445 from the National Center for Advancing Translational Sciences/National Institutes of Health .

Publisher Copyright:
© 2015 Society for Vascular Surgery.

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

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