Predicting survial by cancer pathway gene expression profiles in the TCGA

Hyunsoo Kim, Markus Bredel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Personalized medicine is usually based on known subcategories of a disease for better treatment. Identifying biomarkers that predict disease subtypes has been an important topic in biomédical sciences. There is a controversy as to the optimal number of genes as an input of a feature selection algorithm. In this paper, we investigate the feasibility to use genes pre-selected by biological knowledge rather than all available genes as an input for a feature selection algorithm predicting survival in the glioblastoma of the The Cancer Genome Atlas (TCGA). We discuss the advantage and disadvantage of this approach.

Original languageEnglish (US)
Title of host publicationProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Pages872-875
Number of pages4
DOIs
StatePublished - 2012
Externally publishedYes
Event2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 - Philadelphia, PA, United States
Duration: Oct 4 2012Oct 7 2012

Publication series

NameProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

Conference

Conference2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Country/TerritoryUnited States
CityPhiladelphia, PA
Period10/4/1210/7/12

Keywords

  • brain
  • cancer
  • gene expression
  • survival

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