Precision Editing of Large Animal Genomes

Wenfang Spring Tan, Daniel F. Carlson, Mark W. Walton, Scott C. Fahrenkrug, Perry B. Hackett

Research output: Chapter in Book/Report/Conference proceedingChapter

67 Citations (Scopus)

Abstract

Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.

Original languageEnglish (US)
Title of host publicationAdvances in Genetics
PublisherAcademic Press Inc.
Pages37-97
Number of pages61
DOIs
StatePublished - 2012

Publication series

NameAdvances in Genetics
Volume80
ISSN (Print)0065-2660

Fingerprint

Genome
Food
Genetically Modified Animals
Domestic Animals
Biocompatible Materials
Therapeutics
Population
Proteins

Keywords

  • Allelic introgressioin
  • Cattle
  • Gene-editing
  • Goats
  • Pigs
  • Sheep
  • TAL-Effector Nucleases (TALENs)
  • Transposons
  • Zinc-Finger Nucleases (ZFNs)

Cite this

Tan, W. S., Carlson, D. F., Walton, M. W., Fahrenkrug, S. C., & Hackett, P. B. (2012). Precision Editing of Large Animal Genomes. In Advances in Genetics (pp. 37-97). (Advances in Genetics; Vol. 80). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-404742-6.00002-8

Precision Editing of Large Animal Genomes. / Tan, Wenfang Spring; Carlson, Daniel F.; Walton, Mark W.; Fahrenkrug, Scott C.; Hackett, Perry B.

Advances in Genetics. Academic Press Inc., 2012. p. 37-97 (Advances in Genetics; Vol. 80).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tan, WS, Carlson, DF, Walton, MW, Fahrenkrug, SC & Hackett, PB 2012, Precision Editing of Large Animal Genomes. in Advances in Genetics. Advances in Genetics, vol. 80, Academic Press Inc., pp. 37-97. https://doi.org/10.1016/B978-0-12-404742-6.00002-8
Tan WS, Carlson DF, Walton MW, Fahrenkrug SC, Hackett PB. Precision Editing of Large Animal Genomes. In Advances in Genetics. Academic Press Inc. 2012. p. 37-97. (Advances in Genetics). https://doi.org/10.1016/B978-0-12-404742-6.00002-8
Tan, Wenfang Spring ; Carlson, Daniel F. ; Walton, Mark W. ; Fahrenkrug, Scott C. ; Hackett, Perry B. / Precision Editing of Large Animal Genomes. Advances in Genetics. Academic Press Inc., 2012. pp. 37-97 (Advances in Genetics).
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