Precision Editing of Large Animal Genomes

Wenfang Spring Tan, Daniel F. Carlson, Mark W. Walton, Scott C. Fahrenkrug, Perry B. Hackett

Research output: Chapter in Book/Report/Conference proceedingChapter

86 Scopus citations

Abstract

Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.

Original languageEnglish (US)
Title of host publicationAdvances in Genetics
PublisherAcademic Press Inc.
Pages37-97
Number of pages61
DOIs
StatePublished - 2012

Publication series

NameAdvances in Genetics
Volume80
ISSN (Print)0065-2660

Bibliographical note

Funding Information:
We thank our colleagues in the Center for Genome Engineering for continuing advice and insights into methods for developing precision genetic technologies using chimeric nucleases and transposons. The authors were supported by NIH grants 1R01DK082516 and P01-HD32652 to PBH, and NIH grants 1R43 RR033149 , 1R41HL108440 , and USDA-NIFA BRAG grant 2012-01628 to SCF. We thank Dr. Jerry Taylor for reading portions of this review. We apologize for the selections we have made that inadvertently left out references to work published by our colleagues throughout the world.

Keywords

  • Allelic introgressioin
  • Cattle
  • Gene-editing
  • Goats
  • Pigs
  • Sheep
  • TAL-Effector Nucleases (TALENs)
  • Transposons
  • Zinc-Finger Nucleases (ZFNs)

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