Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions

Katherine Barton, R. Dexter Yellowman, Tara Holm, Forrest Beaulieu, Gabriel Zuckerberg, Kriti Gwal, Bindu N. Setty, Emily Janitz, Misun Hwang

Research output: Contribution to journalReview articlepeer-review

Abstract

Literature examining possible deleterious effects of anesthesia exposure on the developing brain has increased substantially over the past 30 years. Initial concerning findings in animal models, both rodents and non-human primates, prompted increasingly thorough examinations in humans, including randomized controlled trials. This review will provide a concise overview of what we know about anesthesia and the developing brain: the background in animal studies, the most robust results we have in humans, and the work yet to be done. This is particularly relevant to a pediatric radiology audience because we have the unique opportunity to modify anesthesia exposure during imaging through innovation.

Original languageEnglish (US)
Pages (from-to)2143-2156
Number of pages14
JournalPediatric Radiology
Volume54
Issue number13
DOIs
StatePublished - Dec 2024

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

Keywords

  • Anesthesia
  • Animals, newborn
  • Child development
  • Drug toxicity
  • Infant
  • Newborn

PubMed: MeSH publication types

  • Journal Article
  • Review

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