Pre-analytical factors and analytical issues affecting interpretation of cardiovascular biomarkers

Research output: Chapter in Book/Report/Conference proceedingChapter


The Universal Definition of Myocardial Infarction globally endorses cardiac troponin (T and I; cTnT, cTnI) as the biomarker of choice for the diagnosis and assessment of acute coronary syndrome (ACS) and should be utilized routinely in patients with symptoms suggestive of acute myocardial infarction (AMI) [1]. Despite the widespread use of troponin in clinical practice there remain a number of pre-analytical, analytical and interpretive issues which can confound clinical interpretation and will likely be magnified with high-sensitivity troponin assays. The following case studies and discussion highlight some of these issues and nuances associated with troponin assays.

Original languageEnglish (US)
Title of host publicationCardiac Biomarkers
Subtitle of host publicationCase Studies and Clinical Correlations
PublisherSpringer International Publishing
Number of pages13
ISBN (Electronic)9783319429823
ISBN (Print)9783319429809
StatePublished - Jan 1 2016


  • Acute coronary syndrome
  • Antibody
  • Biomarker
  • Chest pain
  • Hemolysis
  • Heterophile
  • High-sensitivity troponin
  • Interferences
  • Myocardial infarction
  • Troponin


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