prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons

Eugenia Olesnicky, Laura Hernandez-Lagunas, Kristin Bruk Artinger

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The PR domain containing 1a, with ZNF domain factor, gene (prdm1a) plays an integral role in the development of a number of different cell types during vertebrate embryogenesis, including neural crest cells, Rohon-Beard (RB) sensory neurons and the cranial neural crest-derived craniofacial skeletal elements. To better understand how Prdm1a regulates the development of various cell types in zebrafish, we performed a microarray analysis comparing wild type and prdm1a mutant embryos and identified a number of genes with altered expression in the absence of prdm1a. Rescue analysis determined that two of these, sox10 and islet1, lie downstream of Prdm1a in the development of neural crest cells and RB neurons, respectively. In addition, we identified a number of other novel downstream targets of Prdm1a that may be important for the development of diverse tissues during zebrafish embryogenesis.

Original languageEnglish (US)
Pages (from-to)656-666
Number of pages11
JournalGenesis
Volume48
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Cell fate
  • Gene regulatory network
  • Neural plate border
  • Transcription factor
  • Zebrafish

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