Pragmatic Design of Randomized Clinical Trials for Heart Failure: Rationale and Design of the TRANSFORM-HF Trial

Keyphrases

• Heart Failure 100%
• Randomized Clinical Trial 100%
• Heart Failure Trials 100%
• Furosemide 100%
• Torsemide 100%
• Pragmatic Design 100%
• Patients with Heart Failure 60%
• Loop Diuretics 60%
• Diuretic Drugs 60%
• United States 40%
• Treatment Strategy 40%
• Practice Guidelines 40%
• Prospective Randomized Trial 20%
• Randomized Trial 20%
• Comparative Effectiveness Studies 20%
• Patient Care 20%
• Patient-reported Outcomes 20%
• Evidence-based Medicine 20%
• Clinical Experience 20%
• Gaps in Knowledge 20%
• Heart Failure Management 20%
• High Cost 20%
• Clinical Outcome Study 20%
• Long-term Mortality 20%
• For Loop 20%
• Data Collection Costs 20%
• Diuretic Therapy 20%
• Absence of Evidence 20%
• Long-stay Patients 20%
• Patient Enrollment 20%
• Heart Failure Guidelines 20%
• Guideline-concordant Care 20%
• Long-term Hospitalization 20%
• Site-based Research 20%
• Global Trial 20%
• Successful Treatment 20%
• Traditional Models 20%
• Healthcare Decisions 20%
• Selected Populations 20%
• Heart Failure Care 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Randomized Clinical Trial 100%
• Congestive Heart Failure 100%
• Furosemide 45%
• Torasemide 45%
• Loop Diuretic Agent 27%
• Clinical Study 9%
• Effectiveness Study 9%
• Diuretic Therapy 9%
• Diuretic Agent 9%