Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO2/H2O

Trinadh Kaicharla; Manikandan Thangaraj; Akkattu T. Biju

doi:10.1021/ol500403x

Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO₂/H₂O

Trinadh Kaicharla
, Manikandan Thangaraj
, Akkattu T. Biju

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO₂ or H₂O have been reported. With CO₂ as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.

Original language	English (US)
Pages (from-to)	1728-1731
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	6
DOIs	https://doi.org/10.1021/ol500403x
State	Published - Mar 21 2014
Externally published	Yes

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10.1021/ol500403x

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title = "Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO2/H2O",

abstract = "Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.",

author = "Trinadh Kaicharla and Manikandan Thangaraj and Biju, \{Akkattu T.\}",

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journal = "Organic Letters",

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AU - Kaicharla, Trinadh

AU - Thangaraj, Manikandan

AU - Biju, Akkattu T.

PY - 2014/3/21

Y1 - 2014/3/21

N2 - Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.

AB - Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.

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Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO₂/H₂O

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