Two practical catalytic asymmetric reductions to introduce the epothilone C15 stereocenter are described (Itsuno-Corey reduction and Noyori hydrogenation).
Bibliographical noteFunding Information:
We gratefully acknowledge financial support from the National Institutes of Health's National Cancer Institute (NCI CA79641) and the General Research Fund at the University of Kansas. E.A.R. acknowledges the NIH training grant (NIH-GM-07775), and the American Foundation for Pharmaceutical Education for fellowships. E.A.R. and J.I. acknowledge the Department of Defense (DAMD 17-00-1-0303) for fellowship support.
Copyright 2008 Elsevier B.V., All rights reserved.
- Antitumor agents
- Asymmetric catalysis
- Itsuno-Corey reduction
- Noyori reduction