Two practical catalytic asymmetric reductions to introduce the epothilone C15 stereocenter are described (Itsuno-Corey reduction and Noyori hydrogenation).
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jul 19 2004|
Bibliographical noteFunding Information:
We gratefully acknowledge financial support from the National Institutes of Health's National Cancer Institute (NCI CA79641) and the General Research Fund at the University of Kansas. E.A.R. acknowledges the NIH training grant (NIH-GM-07775), and the American Foundation for Pharmaceutical Education for fellowships. E.A.R. and J.I. acknowledge the Department of Defense (DAMD 17-00-1-0303) for fellowship support.
- Antitumor agents
- Asymmetric catalysis
- Itsuno-Corey reduction
- Noyori reduction