TY - JOUR
T1 - Practical management of behavioral problems in mucopolysaccharidoses disorders
AU - Escolar, Maria L.
AU - Jones, Simon A.
AU - Shapiro, Elsa G.
AU - Horovitz, Dafne D.G.
AU - Lampe, Christina
AU - Amartino, Hernán
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/12
Y1 - 2017/12
N2 - The mucopolysaccharidosis (MPS) disorders are caused by deficiencies of specific lysosomal enzymes, resulting in progressive glycosaminoglycan (GAG) accumulation in cells and tissues throughout the body. Excessive GAG storage can lead to a variety of somatic manifestations as well as primary and secondary neurological symptoms. Behavioral problems (like hyperactivity, attention difficulties, and severe frustration) and sleeping problems are typical primary neurological symptoms of MPS caused by GAG accumulation in neurons, and are frequently observed in patients with MPS I, II, III, and VII. As these problems often place a significant burden on the family, proper management is important. This review summarizes current insights into behavioral and sleeping problems in MPS disorders and the most optimal management approaches, as presented and discussed during a meeting of an international group of experts with extensive experience in managing and treating MPS.
AB - The mucopolysaccharidosis (MPS) disorders are caused by deficiencies of specific lysosomal enzymes, resulting in progressive glycosaminoglycan (GAG) accumulation in cells and tissues throughout the body. Excessive GAG storage can lead to a variety of somatic manifestations as well as primary and secondary neurological symptoms. Behavioral problems (like hyperactivity, attention difficulties, and severe frustration) and sleeping problems are typical primary neurological symptoms of MPS caused by GAG accumulation in neurons, and are frequently observed in patients with MPS I, II, III, and VII. As these problems often place a significant burden on the family, proper management is important. This review summarizes current insights into behavioral and sleeping problems in MPS disorders and the most optimal management approaches, as presented and discussed during a meeting of an international group of experts with extensive experience in managing and treating MPS.
KW - Behavior
KW - Child behavior disorders
KW - Lysosomal storage diseases
KW - Mental disorders
KW - Mucopolysaccharidoses
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U2 - 10.1016/j.ymgme.2017.09.010
DO - 10.1016/j.ymgme.2017.09.010
M3 - Review article
C2 - 29170079
AN - SCOPUS:85034592051
SN - 1096-7192
VL - 122
SP - 35
EP - 40
JO - Molecular Genetics and Metabolism
JF - Molecular Genetics and Metabolism
ER -