Abstract
The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 546-547 |
| Number of pages | 2 |
| Journal | Archives of Internal Medicine |
| Volume | 140 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1980 |