The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.
|Original language||English (US)|
|Number of pages||2|
|Journal||Archives of Internal Medicine|
|State||Published - Apr 1980|