Potentiation of Warfarin Anticoagulation by Sulfisoxazole

Leo J. Sioris, Robert T. Weibert, Paul R. Pentel

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.

Original languageEnglish (US)
Pages (from-to)546-547
Number of pages2
JournalArchives of Internal Medicine
Issue number4
StatePublished - Apr 1980


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