Potential use of lymphocyte blastogenic responses in diagnosis of bovine tuberculosis

Charles O. Thoen, Jerald L. Jarnagin, Charles C Muscoplat, L. S. Cram, Donald W. Johnson, Rube Harrington

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A comparison of in vitro lymphocyte responses and delayed type tuberculin skin test responses was made in an animal experimentally exposed to a Mycobacterium bovis-infected animal and in cattle naturally infected with M. bovis. Tuberculin skin tests did not suppress in vitro lymphocyte responses to M. bovis PPD and to M. avium PPD tuberculin. The whole blood test used in these studies provided for considerable savings in time as compared to use of purified lymphocytes for evaluating in vitro cellular responses. Variations in the responsiveness of lymphocytes to specific mycobacterial antigens was observed, therefore, it is recommended that profiles be established using three or more tests conducted at 14-day intervals.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalComparative Immunology, Microbiology and Infectious Diseases
Issue number3
StatePublished - 1980


  • In vitro lymphocyte responses
  • Mycobacterium avium PPD
  • Mycobacterium bovis PPD
  • cattle
  • tuberculin skin tests


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