Potential treatment of osteoarthritis by gene therapy

C. H. Evans, Paul D Robbins

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Recent advances in understanding the biology of osteoarthritis have allowed the design of novel therapeutic strategies based on biologic principals. Gene therapy is one such strategy. The underlying concept is to deliver to patients with OA genes that have products with antiarthritic properties. This results in the endogenous production of these products in a sustained and ultimately regulated fashion, thereby obviating the problems that exist with traditional methods of drug delivery. Synovium and articular cartilage are two attractive sites for the delivery of anti-OA genes. Preliminary experimental data support the use of these concepts.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalRheumatic Disease Clinics of North America
Volume25
Issue number2
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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