Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia

Anna T. Meadows; Leslie L. Robison; Joseph P. Neglia; Harland Sather; Denman Hammond; Ching Hon Pui; Gaston K. Rivera; William M. Crist; Charmian Quigley; Christopher Cowell; Mark Jimenez; Henry Burger; Judy Kirk; Mary Bergin; Michael Stevens; Judy Simpson; Martin Silink

doi:10.1056/NEJM198912283212612

Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia

Anna T. Meadows
, Leslie L. Robison
, Joseph P. Neglia
, Harland Sather
, Denman Hammond
, Ching Hon Pui
, Gaston K. Rivera
, William M. Crist
, Charmian Quigley
, Christopher Cowell
, Mark Jimenez
, Henry Burger
, Judy Kirk
, Mary Bergin
, Michael Stevens
, Judy Simpson
, Martin Silink

Pediatric Hematology/Oncology

Research output: Contribution to journal › Letter › peer-review

14 Scopus citations

Abstract

To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.¹ ² ³ Members of the Children's Cancer Study Group have been assessing the effect of previous treatment on the lives of such patients who survive for many years. The study group recently completed a follow-up of 9720 patients with acute lymphoblastic leukemia (ALL) who have been treated in trials conducted by the group since 1972.⁴ In this cohort, representing more than 43,000 person-years of follow-up, with more than 2400 patients followed for seven years…

Original language	English (US)
Pages (from-to)	1830-1831
Number of pages	2
Journal	New England Journal of Medicine
Volume	321
Issue number	26
DOIs	https://doi.org/10.1056/NEJM198912283212612
State	Published - Dec 28 1989

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SDG 3 Good Health and Well-being

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Meadows, A. T., Robison, L. L., Neglia, J. P., Sather, H., Hammond, D., Pui, C. H., Rivera, G. K., Crist, W. M., Quigley, C., Cowell, C., Jimenez, M., Burger, H., Kirk, J., Bergin, M., Stevens, M., Simpson, J., & Silink, M. (1989). Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia. New England Journal of Medicine, 321(26), 1830-1831. https://doi.org/10.1056/NEJM198912283212612

Meadows, AT, Robison, LL, Neglia, JP, Sather, H, Hammond, D, Pui, CH, Rivera, GK, Crist, WM, Quigley, C, Cowell, C, Jimenez, M, Burger, H, Kirk, J, Bergin, M, Stevens, M, Simpson, J & Silink, M 1989, 'Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia', New England Journal of Medicine, vol. 321, no. 26, pp. 1830-1831. https://doi.org/10.1056/NEJM198912283212612

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abstract = "To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.1 2 3 Members of the Children's Cancer Study Group have been assessing the effect of previous treatment on the lives of such patients who survive for many years. The study group recently completed a follow-up of 9720 patients with acute lymphoblastic leukemia (ALL) who have been treated in trials conducted by the group since 1972.4 In this cohort, representing more than 43,000 person-years of follow-up, with more than 2400 patients followed for seven years…",

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doi = "10.1056/NEJM198912283212612",

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AU - Meadows, Anna T.

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AU - Neglia, Joseph P.

AU - Sather, Harland

AU - Hammond, Denman

AU - Pui, Ching Hon

AU - Rivera, Gaston K.

AU - Crist, William M.

AU - Quigley, Charmian

AU - Cowell, Christopher

AU - Jimenez, Mark

AU - Burger, Henry

AU - Kirk, Judy

AU - Bergin, Mary

AU - Stevens, Michael

AU - Simpson, Judy

AU - Silink, Martin

PY - 1989/12/28

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N2 - To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.1 2 3 Members of the Children's Cancer Study Group have been assessing the effect of previous treatment on the lives of such patients who survive for many years. The study group recently completed a follow-up of 9720 patients with acute lymphoblastic leukemia (ALL) who have been treated in trials conducted by the group since 1972.4 In this cohort, representing more than 43,000 person-years of follow-up, with more than 2400 patients followed for seven years…

AB - To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.1 2 3 Members of the Children's Cancer Study Group have been assessing the effect of previous treatment on the lives of such patients who survive for many years. The study group recently completed a follow-up of 9720 patients with acute lymphoblastic leukemia (ALL) who have been treated in trials conducted by the group since 1972.4 In this cohort, representing more than 43,000 person-years of follow-up, with more than 2400 patients followed for seven years…

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Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia

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