Potential Long-Term Toxic Effects in Children Treated for Acute Lymphoblastic Leukemia

Anna T. Meadows, Leslie L. Robison, Joseph P. Neglia, Harland Sather, Denman Hammond, Ching Hon Pui, Gaston K. Rivera, William M. Crist, Charmian Quigley, Christopher Cowell, Mark Jimenez, Henry Burger, Judy Kirk, Mary Bergin, Michael Stevens, Judy Simpson, Martin Silink

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.1 2 3 Members of the Children's Cancer Study Group have been assessing the effect of previous treatment on the lives of such patients who survive for many years. The study group recently completed a follow-up of 9720 patients with acute lymphoblastic leukemia (ALL) who have been treated in trials conducted by the group since 1972.4 In this cohort, representing more than 43,000 person-years of follow-up, with more than 2400 patients followed for seven years…

Original languageEnglish (US)
Pages (from-to)1830-1831
Number of pages2
JournalNew England Journal of Medicine
Issue number26
StatePublished - Dec 28 1989


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