Abstract
PURPOSE: To show the potential for gene-gene confounding bias in case-parental control studies. METHODS: The authors quantify the magnitude of gene-gene confounding bias using simple mathematical equations. They also demonstrate the potential problems of such a bias with hypothetical (but realistic) examples. RESULTS: The degree of bias resulting from gene-gene confounding was found to be quite substantial under certain conditions (two genes are very closely linked and/or the study was performed in a recently admixed population). CONCLUSION: In this post-genomic era more and more encounters of the gene-gene confounding will be expected, if the one-gene-at-a-time approach continues to be adopted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-266 |
| Number of pages | 6 |
| Journal | Annals of epidemiology |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2003 |
| Externally published | Yes |
Bibliographical note
Funding Information:This study was partly supported by a grant from the National Science Council, Republic of China.
Keywords
- Case-Parental Control Study
- Confounding
- Epidemiologic Methods
- Genetic Epidemiology
- Genotype Relative Risk
- Transmission/Disequilibrium Test
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