Potential for gene-gene confounding bias in case-parental control studies

Wen Chung Lee; Yen Yi Ho

doi:10.1016/S1047-2797(02)00410-6

Potential for gene-gene confounding bias in case-parental control studies

Wen Chung Lee, Yen Yi Ho

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

PURPOSE: To show the potential for gene-gene confounding bias in case-parental control studies. METHODS: The authors quantify the magnitude of gene-gene confounding bias using simple mathematical equations. They also demonstrate the potential problems of such a bias with hypothetical (but realistic) examples. RESULTS: The degree of bias resulting from gene-gene confounding was found to be quite substantial under certain conditions (two genes are very closely linked and/or the study was performed in a recently admixed population). CONCLUSION: In this post-genomic era more and more encounters of the gene-gene confounding will be expected, if the one-gene-at-a-time approach continues to be adopted.

Original language	English (US)
Pages (from-to)	261-266
Number of pages	6
Journal	Annals of epidemiology
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/S1047-2797(02)00410-6
State	Published - Apr 2003
Externally published	Yes

Bibliographical note

Funding Information:
This study was partly supported by a grant from the National Science Council, Republic of China.

Keywords

Case-Parental Control Study
Confounding
Epidemiologic Methods
Genetic Epidemiology
Genotype Relative Risk
Transmission/Disequilibrium Test

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10.1016/S1047-2797(02)00410-6

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title = "Potential for gene-gene confounding bias in case-parental control studies",

abstract = "PURPOSE: To show the potential for gene-gene confounding bias in case-parental control studies. METHODS: The authors quantify the magnitude of gene-gene confounding bias using simple mathematical equations. They also demonstrate the potential problems of such a bias with hypothetical (but realistic) examples. RESULTS: The degree of bias resulting from gene-gene confounding was found to be quite substantial under certain conditions (two genes are very closely linked and/or the study was performed in a recently admixed population). CONCLUSION: In this post-genomic era more and more encounters of the gene-gene confounding will be expected, if the one-gene-at-a-time approach continues to be adopted.",

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doi = "10.1016/S1047-2797(02)00410-6",

language = "English (US)",

volume = "13",

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journal = "Annals of epidemiology",

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TY - JOUR

T1 - Potential for gene-gene confounding bias in case-parental control studies

AU - Lee, Wen Chung

AU - Ho, Yen Yi

N1 - Funding Information: This study was partly supported by a grant from the National Science Council, Republic of China.

PY - 2003/4

Y1 - 2003/4

N2 - PURPOSE: To show the potential for gene-gene confounding bias in case-parental control studies. METHODS: The authors quantify the magnitude of gene-gene confounding bias using simple mathematical equations. They also demonstrate the potential problems of such a bias with hypothetical (but realistic) examples. RESULTS: The degree of bias resulting from gene-gene confounding was found to be quite substantial under certain conditions (two genes are very closely linked and/or the study was performed in a recently admixed population). CONCLUSION: In this post-genomic era more and more encounters of the gene-gene confounding will be expected, if the one-gene-at-a-time approach continues to be adopted.

AB - PURPOSE: To show the potential for gene-gene confounding bias in case-parental control studies. METHODS: The authors quantify the magnitude of gene-gene confounding bias using simple mathematical equations. They also demonstrate the potential problems of such a bias with hypothetical (but realistic) examples. RESULTS: The degree of bias resulting from gene-gene confounding was found to be quite substantial under certain conditions (two genes are very closely linked and/or the study was performed in a recently admixed population). CONCLUSION: In this post-genomic era more and more encounters of the gene-gene confounding will be expected, if the one-gene-at-a-time approach continues to be adopted.

KW - Case-Parental Control Study

KW - Confounding

KW - Epidemiologic Methods

KW - Genetic Epidemiology

KW - Genotype Relative Risk

KW - Transmission/Disequilibrium Test

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SN - 1047-2797

VL - 13

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EP - 266

JO - Annals of epidemiology

JF - Annals of epidemiology

IS - 4

ER -

Potential for gene-gene confounding bias in case-parental control studies

Abstract

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Keywords

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