Potential drug-drug interactions on a tertiary-care hospital consultation-liaison psychiatry service

David E. Adson, Scott J. Crow, William H. Meller, Richard M. Magraw

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Pharmacokinetic interactions involving the cytochrome P450 system have been a recent focus of clinical and research interest in psychopharmacology. The authors reviewed 100 consecutive patients seen on a consultation-liaison (C-L)psychiatry service for potential drug-drug interactions. The patients were taking a mean of 8.8 medications; for those undergoing organ transplantation the mean was 12.9. While both enzyme inhibitors (n = 87) and substrates (n = 89) were commonly used, only rarely were they used in the same patient (n = 14). The authors conclude that the potential for drug interactions on a C-L psychiatry service is significant, necessitating awareness of this potential complication.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalPsychosomatics
Volume39
Issue number4
DOIs
StatePublished - Jan 1 1998

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