Potential approaches for heterologous prion protein treatment of prion diseases

Davis M. Seelig, Patricia A. Goodman, Pamela J. Skinner

Research output: Contribution to journalComment/debate

5 Scopus citations

Abstract

Prion diseases, or transmissible spongiform encephalopathies (TSEs) are progressive, fatal neurodegenerative diseases with no effective treatment. The pathology of these diseases involves the conversion of a protease sensitive form of the cellular prion protein (PrPC) into a protease resistant infectious form (PrPres). The efficiency of this conversion is predicated upon a number of factors, most notably a strong homology between cellular PrPC and PrPres. In our recently published study, we infected mice with the RML-Chandler strain of scrapie and treated them with heterologous hamster prion proteins. This treatment was seen to reduce clinical signs of prion disease, to delay the onset of clinical symptoms and to prolong survival. In this current article we discuss potential mechanisms of action of treatment with heterologous prion proteins. We also discuss potential extensions of these studies using a heterologous rabbit PrP-based treatment strategy or a peptide based strategy, and improvement of treatment delivery including a lentiviral-based system.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalPrion
Volume10
Issue number1
DOIs
StatePublished - Jan 2 2016

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Keywords

  • PrP
  • PrP
  • heterologous prion proteins
  • prion
  • treatment

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