Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro

Robert Vince; Mei Hua; Jay Brownell; Susan Daluge; Fangchen Lee; William M. Shannon; George C. Lavelle; Jeanine Qualls; Owen S. Weislow; Rebecca Kiser; Peter G. Canonico; Robert H. Schultz; V. L. Narayanan; Joseph G. Mayo; Robert H. Shoemaker; Michael R. Boyd

doi:10.1016/S0006-291X(88)80950-1

Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro

Robert Vince
, Mei Hua
, Jay Brownell
, Susan Daluge
, Fangchen Lee
, William M. Shannon
, George C. Lavelle
, Jeanine Qualls
, Owen S. Weislow
, Rebecca Kiser
, Peter G. Canonico
, Robert H. Schultz
, V. L. Narayanan
, Joseph G. Mayo
, Robert H. Shoemaker
, Michael R. Boyd

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

228 Scopus citations

Abstract

Carbocyclic 2′,3′-didehydro-2′,3′-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.

Original language	English (US)
Pages (from-to)	1046-1053
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	156
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(88)80950-1
State	Published - Oct 31 1988

Bibliographical note

Funding Information:
This work was supported by NIH grant R01 CA23263, NCl contract NO1-CA-74102, and USAMRIID contract DAMD17-86-C-6013.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Vince, R., Hua, M., Brownell, J., Daluge, S., Lee, F., Shannon, W. M., Lavelle, G. C., Qualls, J., Weislow, O. S., Kiser, R., Canonico, P. G., Schultz, R. H., Narayanan, V. L., Mayo, J. G., Shoemaker, R. H., & Boyd, M. R. (1988). Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro. Biochemical and Biophysical Research Communications, 156(2), 1046-1053. https://doi.org/10.1016/S0006-291X(88)80950-1

Vince, R, Hua, M, Brownell, J, Daluge, S, Lee, F, Shannon, WM, Lavelle, GC, Qualls, J, Weislow, OS, Kiser, R, Canonico, PG, Schultz, RH, Narayanan, VL, Mayo, JG, Shoemaker, RH & Boyd, MR 1988, 'Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro', Biochemical and Biophysical Research Communications, vol. 156, no. 2, pp. 1046-1053. https://doi.org/10.1016/S0006-291X(88)80950-1

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title = "Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro",

abstract = "Carbocyclic 2′,3′-didehydro-2′,3′-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.",

author = "Robert Vince and Mei Hua and Jay Brownell and Susan Daluge and Fangchen Lee and Shannon, \{William M.\} and Lavelle, \{George C.\} and Jeanine Qualls and Weislow, \{Owen S.\} and Rebecca Kiser and Canonico, \{Peter G.\} and Schultz, \{Robert H.\} and Narayanan, \{V. L.\} and Mayo, \{Joseph G.\} and Shoemaker, \{Robert H.\} and Boyd, \{Michael R.\}",

note = "Funding Information: This work was supported by NIH grant R01 CA23263, NCl contract NO1-CA-74102, and USAMRIID contract DAMD17-86-C-6013.",

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AU - Daluge, Susan

AU - Lee, Fangchen

AU - Shannon, William M.

AU - Lavelle, George C.

AU - Qualls, Jeanine

AU - Weislow, Owen S.

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AU - Schultz, Robert H.

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AU - Mayo, Joseph G.

AU - Shoemaker, Robert H.

AU - Boyd, Michael R.

N1 - Funding Information: This work was supported by NIH grant R01 CA23263, NCl contract NO1-CA-74102, and USAMRIID contract DAMD17-86-C-6013.

PY - 1988/10/31

Y1 - 1988/10/31

N2 - Carbocyclic 2′,3′-didehydro-2′,3′-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.

AB - Carbocyclic 2′,3′-didehydro-2′,3′-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.

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Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro

Abstract

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